姓名：崔岩
邮箱：yan.cui@muhn.edu.cn
教育经历：
1996/09—2001/07，北京大学医学部，基础医学，学士
2001/09—2004/07，上海中医药大学，中西医结合基础，硕士
2006/08—2007/08，香港中文大学临床肿瘤学系，肿瘤表观遗传学，博士研究生
2007/10—2012/04，德国莱布尼兹衰老研究所/耶拿大学，肿瘤细胞生物学，博士
工作经历：
2004/06—2004/12，约翰斯·霍普金斯新加坡分部，研究助理
2004/12—2006/07，香港中文大学临床肿瘤学系，研究助理
2012/05—2021/08，德国莱布尼兹衰老研究所，博士后
2021/10—至今，海南医科大学（原海南医学院），衰老与肿瘤国际研究中心，科研人员
研究方向：
肿瘤信号转导与分子机理；靶向治疗；生物技术开发
研究内容：
1. 神经纤维瘤2型基因（NF2）编码产物merlin的信号通路和分子机理研究
2. 肿瘤或衰老相关基因功能及作用机制
Name: Yan Cui
Email: yan.cui@muhn.edu.cn
Education background:
1996/09—2001/07, Peking University Health Science Center, Basic medical science, Bachelor
2001/09—2004/07, Shanghai University of Traditional Chinese Medicine, Physiology, Master
2006/08—2007/08, Department of Clinical Oncology, the Chinese University of Hong Kong, Cancer epigenetics, PhD student
2007/10—2012/04, Leibniz Institute on Aging/Jena University, Tumor cell biology, PhD
Work experience:
2004/06—2004/12, Division of Johns Hopkins in Singapore, Research fellow
2004/12—2006/07, Department of Clinical Oncology, the Chinese University of Hong Kong, Research assistant
2012/05—2021/08, Leibniz Institute on Aging, Post-doc
2021/10—Present, International Center for Aging and Cancer, Hainan Medical University, Research faculty
Research Area:
Cancer cell signaling and the molecular mechanisms; targeted therapies; biotechniques
Research Interests:
1. The signaling pathways and the molecular mechanisms of the tumor suppressor merlin, the neurofibromatosis type 2 (NF2) gene product
2. The functions and action mechanisms of genes related to cancer or aging
Selected publications（#first author, *Corresponding author）
(1) Li, Na#; Cai, Ying#; Zou, Min; Zhou, Jian; Zhang, Ling; Zhou, Liquan; Xiang, Wenpei*; Cui, Yan*; Li, Huaibiao*; CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos, Stem Cell Reports, 2022, 18(1): 81-96
(2) Cui, Yan*; Ma, Lin; Schacke, Stephan; Yin, Jiani C; Hsueh, Yi-Ping; Jin, Hongchuan; Morrison, Helen*; Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway, Human Molecular Genetics, 2021, 29(23): 3793-3806
(3) Cui, Yan#*; Groth, Susann#; Troutman, Scott; Carlstedt, Annemarie; Sperka, Tobias; Riecken, Lars Björn; Kissil, Joseph L; Jin, Hongchuan; Morrison, Helen*; The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling, Oncogene, 2019, 38(36): 6370-6381
(4) Cui, Yan*; Morrison, Helen*; Construction of cloning-friendly minigenes for mammalian expression of full-length human NF1 isoforms, Human Mutation, 2019, 40(2): 187-192
(5) Han, Shuting; Cui, Yan*; Helbing, Dario L; Inactivation of Horseradish Peroxidase by Acid for Sequential Chemiluminescent Western Blot, Biotechnology Journal, 2020, 15(3): 0-e1900397
