个人简历

2023-09 至 今, 助理研究员，海南医科大学, 生命科学与医学技术学院

2023-09 至 今, 助理研究员，海南医学院, 海南省医学科学院,

2022-03 至 今, 助理研究员，海南医学院, 急诊创伤学院,

2018.09 ~ 2021.12，分析化学博士，武汉大学 化学与分子科学学院（生化分析教育部重点实验室）

2015.09 ~ 2018.06，理学学士，曲阜师范大学化学化工与材料科学学院，化学专业

2011.09 ~ 2015.06，理学硕士，曲阜师范大学化学化工与材料科学学院，化学专业

海南省青年人才项目入选者，海南省高层次D类人才，海南医科大学领军人才。研究方向“功能分子工程与化学生物学”, 专注于生物医学功能性荧光分子的构筑、疾病微环境的调控与成像分析研究，创新了"靶标激活型近红外二区有机分子框架设计"、脑区多分子联动协同应激响应检测"等新技术，并应用于生命活性物种实时成像分析、光学引导肿瘤、脑科学等领域研究。近五年以通讯作者（第一）在Angewandte Chemie International Edition, CCS Chemistry, Chemical Science, Biomaterials, Analytical Chemistry等SCI一区等高水平期刊10余篇。论文总引500余次，单篇最高引用150余次。主持国家自然科学基金青年项目、海南省南海新星科技创新人才项目，海南省重点研发计划，海南省自然科学基金等项目。

1：Kun Dou*, Jiao Lu, Yanlong Xing, Rui Wang, Miae Won, Jungryun Kim, Fabiao Yu and Jong Seung Kim. Metabolic Acidity/H₂O₂ Dual-Cascade-Activatable Molecular Imaging Platform Toward Metastatic Breast Tumor Malignancy. Angew. Chem. Int. Ed. 2025, 64, e202419191. (IF: 16.1, SCI 一区TOP, 通讯作者).

2：Guiling Zhao, Xunkai Wang, Muyan Wen, Keyu Wang, Xichen Gao, Kun Dou*, and Fabiao Yu. Near-Infrared Fluorescence Reporter Offering Real-Time Tracking and Differential Assessment of Ferroptosis Progressions In Vivo. Anal. Chem. 2025, 97, 21, 11279–11287 (IF=6.7, 通讯作者).

3：Jiao Lu, Guiling Zhao, Yonghai Wang, Rui Wang, Yanlong Xing, Fabiao Yu*, Kun Dou*. A Tandem-Locked Fluorescent Probe Activated by Hypoxia and a Viscous Environment for Precise Intraoperative Imaging of Tumor and Instant Assessment of Ferroptosis-Mediated Therapy. Anal. Chem. 2024, 96, 19134-19146. (IF=6.7, 通讯作者).

4: Kun Dou; Chen Fan; Wenqi Feng; Yao Kong; Yunhui Xiang; Zijun Wang; Zhihong Liu. “Dual-lock-dual-key” NIR-II molecular probe for specific discrimination of orthotopic colon cancer andimaging-guided tumor excision, CCS Chem. 2022, 4, 3567–3584., 2021, 3: 3567-3584. (IF: 11.2, 第一作者).

5: Kun Dou, Q. Fu, G. Chen, F. Yu, Y. Liu, Z. Cao, G. Li, L. Chen, J. You. A novel dual-ratiometric-response fluorescent probe for SO₂/ClO⁻ detection in cells and in vivo and its application in exploring the dichotomous role of SO₂ under the ClO− induced oxidative stress. Biomaterials, 2017, 133, 82-93 (IF: 12.479, 第一作者).

6: Kun Dou, Guang Chen, Fabiao Yu, Yuxia Liu, and Jinmao You. Bright and sensitive ratiometric fluorescent probe enabling endogenous FA imaging and mechanistic exploration of indirect oxidative damage due to FA in various living systems. Chem. Sci. 2017, 8, 7851-7861 (IF: 9.825, 第一作者).

7: Kun Dou, Weijing Huang, Yunhui Xiang, Songjiao Li, and Zhihong Liu. Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations. Analytical Chemistry, Anal. Chem. 2020, 92, 4177-4181 (中国科学院一区 TOP IF: 6.986, 第一作者).

8: Kun Dou, Wenqi Feng, Chen Fan, Yu Cao, Yunhui Xiang, and Zhihong Liu. Flexible Designing Strategy to Construct Activatable NIR-II Fluorescent Probes with Emission Maxima beyond 1200 nm. Anal. Chem. 2021, 93, 4006-4014. (第一作者，中国科学院一区 TOP IF: 6.986).

9: Lu, Jiao; Dou, Kun*; Geng, Zhirong; Wang, Zhilin. Construction of near infrared ratiometric fluorescent probes with emission crosstalk-free for reversible ATP tracking in mitochondria and tumors, Sens. Actuators. B. Chem., 2023, 390: 0-134043. (IF 8.0, 通讯作者).

10: Jiao Lu, Yonghai Wang, Rui Wang Xianzhu Luo, Yanlong Xing, Fabiao Yu, Kun Dou*. Molecular engineering to construct the high-performance activatable Near-infrared-II fluorogenic sensor for in vivo glutathione imaging and its clinical application. Sens. Actuators. B. Chem., 2025, 438: 137731. (IF 8.0, 通讯作者).

11: Yonghai Wang, Guiling Zhao, Yu Liu, Rui Wang, Yanlong Xing, Kun Dou*, Fabiao Yu. Glutathione-activated near-infrared II fluorescent probe for lung metastatic diagnosis and intraoperative imaging of tumor. Sens. Actuators. B. Chem., 2025, 426: 137005. (IF 8.0, 通讯作者).

12：Yunhui Xiang, Jiao Lu, Wang Rui, Yang Yu, Muyan Wen, Fabiao Yu, Kun Dou*. Visualizing peroxynitrite dynamics in an epilepsy model using an endoplasmic reticulum-targeted fluorescent probe. Sens. Actuators. B. Chem., 2025, 444: 138398. (IF 8.0, 通讯作者).

1. 一种近红外比率型荧光探针及其制备方法和应用

申请号：202310312759.2

发明人：窦昆，陆姣，于法标，邢艳珑，程子译，王锐