导师简介
一、个人信息：
张轩博，现任海南医科大学药学院副研究员。2022年12月博士毕业于沈阳药科大学药剂学专业，曾受国家留学基金委资助赴新加坡国立大学进行联合培养，并在南方医科大学完成博士后研究工作。目前研究方向聚焦于“免疫微环境时空演化与精准干预”。累计参与发表论文40余篇，H指数31（Google scholar），其中以第一或共同第一作者身份在ACS Nano，Chemical Society Reviews、Nature Communications等期刊发表SCI论文10篇，申请发明专利5项，授权3项，主持国家自然科学基金青年基金项目1项。
二、教育经历：
2019.09 – 2022.12：沈阳药科大学 ，药剂学 ，博士
2022.01 – 2023.01：新加坡国立大学 ， 药物递送 ，国家公派联合培养（CSC）
2016.09 – 2019.06：沈阳药科大学，药剂学，硕士
2012.09 – 2016.06：湖北中医药大学，药学，本科
三、主要工作经历：
2025.07 – 至今：海南医科大学药学院，副研究员
2024.01 – 2025.05：新加坡国立大学杨潞龄医学院，Visiting Research Fellow
2023.03 – 2025.06：南方医科大学，博士后
四、学术成果：
论文成果：
1) Xuanbo Zhang♯; Shipeng Ning♯; Feng Fang♯; Cao Zhou; Zifan Yang; Liping Cao; Kaiyuan Wang; Zunyong Feng; Bingyu Li; Dixian Luo; Xiao Xu*; Zhigang Liu*; Xiaoyuan Chen*; Zhiqiang Yu*, Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy. ACS Nano, 2025, 20 (1), 1448-1461. (IF:17.1）
2) Xuanbo Zhang♯; Kaiyuan Wang♯; Zhiqiang Zhao♯; Xinzhu Shan; Yuequan Wang; Zunyong Feng; Bingyu Li; Cong Luo; Xiaoyuan Chen; Jin Sun, Self-Adjuvanting Polyguanidine Nanovaccines for Cancer Immunotherapy. ACS Nano, 2024, 18 (9), 7136-7147. (IF:17.1）
3) Xuanbo Zhang; Jianchen Xiong; Kaiyuan Wang; Han Yu; Bingjun Sun; Hao Ye; Zhiqiang Zhao; Ning Wang; Yuequan Wang; Shenwu Zhang; Wutong Zhao; Haotian Zhang; Zhonggui He; Cong Luo; Jin Sun, Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy. Bioactive Materials, 2021, 6 (8), 2291-2302. (IF:18.9）
4) Xuanbo Zhang; Bowei Yang; Qianqian Ni; Xiaoyuan Chen, Materials engineering strategies for cancer vaccine adjuvant development. Chemical Society Reviews, 2023, 52 (9), 2886-2910. (IF:46.2）
5) Xuanbo Zhang; Bingjun Sun; Shiyi Zuo; Qin Chen; Yanlin Gao; Hanqing Zhao; Mengchi Sun; Pengyu Chen; Han Yu; Wenjuan Zhang; Kaiyuan Wang; Ruoshi Zhang; Qiming Kan; Haotian Zhang; Zhonggui He; Cong Luo; Jin Sun, Self-Assembly of a Pure Photosensitizer as a Versatile Theragnostic Nanoplatform for Imaging-Guided Antitumor Photothermal Therapy. ACS Applied Materials & Interfaces, 2018, 10 (36), 30155-30162. (IF:9.5）
6) Xuanbo Zhang; Na Li; Shenwu Zhang; Bingjun Sun; Qin Chen; Zhonggui He; Cong Luo; Jin Sun, Emerging carrier-free nanosystems based on molecular self-assembly of pure drugs for cancer therapy. Medicinal Research Reviews, 2020, 40 (5), 1754-1775. (IF:13.3）
7) Xuanbo Zhang, Feng Fang, Na Li, Huicong Zhang, Kaiyuan Wang, Zhiqiang Yu, Jin Sun, From reversible to irreversible: Albumin-hitchhiking gemcitabine prodrugs for enhanced antitumor efficacy and reduced toxicity, Chinese Chemical Letters 2026, 37(2), 111452.
8) Kaiyuan Wang♯; Xuanbo Zhang♯; Hao Ye; Xia Wang; Zhijin Fan; Qi Lu; Songhao Li; Jian Zhao; Shunzhe Zheng; Zhonggui He; Qianqian Ni; Xiaoyuan Chen; Jin Sun, Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy. Nature Communications, 2023, 14 (1), 6748. (IF: 16.60）（共同第一作者）
9) Zhiqiang Zhao♯; Xuanbo Zhang♯; Hongyuan Zhang; Xinzhu Shan; Meiyu Bai; Zhe Wang; Fujun Yang; Haotian Zhang; Qiming Kan; Bingjun Sun; Jin Sun; Zhonggui He; Cong Luo, Elaborately Engineering a Self-Indicating Dual-Drug Nanoassembly for Site-Specific Photothermal-Potentiated Thrombus Penetration and Thrombolysis. Advanced Science, 2022, 9 (4), e2104264. (IF:15.1）（共同第一作者）
10) Zunyong Feng; Xuanbo Zhang; Jing Zhou; Qiang Li; Liuxi Chu; Guangfu Di; Zhengyuan Xu; Qun Chen; Ming Wang; Xiaochun Jiang; Hongping Xia; Xiaoyuan Chen, An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2(+)/PTBP1(+) pan-adenocarcinoma. Nature Cancer, 2024, 5 (1), 30-46.
主持科学基金项目：
(1) 国家自然科学基金委员会, 青年科学基金项目, 82404553, 程序性动态活化型递送系统调控肿瘤免疫微环境及克服免疫细胞耗竭机制研究, 2025-01-01 至 2027-12-31, 30万元, 在研, 主持
五、联系方式：
xuanbo.zhang@muhn.edu.cn
