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个人简介
谭鹏，研究员，博士生导师，海南省医学科学院课题组长，广东省珠江青年拔尖人才。美国 Texas A&M University 获得博士学位，毕业后加入麻省理工-哈佛大学博德研究所 Aviv Regev 和 Ramnik Xavier 课题组进行博士后研究，主要从事炎症相关疾病的跨尺度调控网络和系统性机制研究，包括解码宿主先天免疫防御机制和抗病毒药物靶点，研究中性粒细胞和肠道微生物菌群在炎症和肿瘤发生发展与免疫逃逸中的作用，利用光遗传学、细胞图谱和功能基因组学研究脑-体互作与炎症传播。承担美国克罗恩病和溃疡性结肠炎基金会（CCFA）SRA 和 IBD Plexus 项目，国家自然科学基金委面上项目。中国神经科学学会会员，中国免疫学学会会员。发表 SCI 论文 40 篇，总影响因子 >750, 谷歌引用 3900 余次，其中主要原创研究成果以第一或通讯作者论文 17 篇，发表在 Science、Nature Chemical Biology 、Nucleic Acids Research、Molecular Cell、Journal of Clinical Investigation 等国际主流学术期刊上。
学习和工作经历
2025.04-至今 海南医科大学
2019.10-2025.03 麻省理工学院-哈佛大学博德研究所，霍华德休斯医学研究所，博士后
2018.06-2019.10 美国康奈尔大学医学院休斯顿卫理公会医院，博士后
2011.09-2018.05 美国德克萨斯农工大学，博士
研究方向
系统研究炎症动态演化过程中的固有免疫机制和组织器官区域化的神经免疫特征。
代表性成果
第一作者#，通讯作者*
神经免疫与空间多组学方向
1. Tan P#, Jaiswal A#, Murphy S, Su C, Brown E, Hailey W, Finan E, Jasso G, Shi H, Graham D, Delorey T, Deguine J, Xavier R*. Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation. Science (Accepted)
2. Tan P*, Hong T, Cai X, Li W, Huang Y, He L*, Zhou Y*. Optogenetic control of protein delivery and partition in the nucleolus. Nucleic Acids Research 2022, 8;50(12):e69.
3. Shi H, He Y, Zhou Y, Huang J, Maher K, Wang B, Tang Z, Luo S, Tan P, Wu M, Lin Z, Ren J, Thapa Y, Tang X, Liu A, Liu J, Wang X. Spatial atlas of the mouse central nervous system at molecular resolution. Nature 2023, 622(7983):552-561.
光遗传学免疫调控方向
4. Tan P#, He L#, Huang Y*, Zhou Y*. Optophysiology: Illuminating cell physiology with optogenetics. Physiological Reviews 2022,102(3):1263-65.
5. Tan P#, He L#, Han G, Zhou Y.Optogenetic immunomodulation: shedding light on the antitumor immunity. Trends in Biotechnology 2016, 35(3): 215-226.
6. He L#, Tan P#, Zhu L#, Huang K#, Nguyen N, Wang R, Guo L, Li L, Yang Y, Huang Z, Li L, Huang Y, Han G, Wang J, Zhou Y. Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering. Nature Chemical Biology 2021, 17(8):915-923.
7. He L#, Zhang Y#, Ma G#, Tan P#, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan PG, Han G, Zhou Y.Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife 2015, 4: e10024.
8. Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nature Cell Biology 2015, 17(10):1339-47.
9. He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Fei D, Siwko S, Huang Y, Wang Y, Zhou Y.Engineering of a bona fide light-operated calcium channel. Nature Communications 2021, 12(1):164.
10. Li A, Cho J, Reid B, Tseng C, He L, Tan P, Yeh C, Wu P, Li Y, Widelitz R, Zhou Y, Zhao M, Chow R, Chuong CM.Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nature Communications 2018, 9(1):5377.
肿瘤免疫方向
11. Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang Y, Wang RF. Myeloid loss of Beclin1 promotes PD-L1(hi) precursor B cell lymphoma development. Journal of Clinical Investigation 2020, 129(12):5261-5277.
12. Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, Zhou Y. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biology 2018, 16(11):e3000051.
13. Zhang J#, Tan P#, Guo L#, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao W, Dashwood R, Han L, Zhou Y, Dong W, Huang Y. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene 2018, 38(11):1905-1919.
14. Xing C, Wang M, Ajibade A, Tan P, Fu C, Chen L, Zhu M, Hao Z, Chu J, Yu X, Yin B, Zhu J, Shen W, Duan T, Wang Y, Wang RF. Microbiota regulate innate immune signaling and protective immunity against cancer. Cell Host & Microbe 2021, 29:1-16.
15. Zhu M, Deng G, Tan P, Xing C, Guan C, Jiang C, Ning B, Wang H, Chen K, Zhao Y, Wang Y, Levine B, Nie G, Wang RF. Beclin 2 negatively regulates innate immune signaling and tumor development. Journal of Clinical Investigation 2020, 130(10):5349-5369.
固有免疫方向
16. Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu Xiao, Wang Y, Wang RF. Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling. Molecular Cell 2017, 68 (2): 293-307.
17. Zhu Q#, Tan P#, Li Y, Lin M, Cui J, Zhao W, Song Y, Li Q, Akira S, Wang H, Wang RF. DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity. PLoS Pathogens 2018, 14(2): e1006886.
18. Muus C, Luecken M, Eraslan G, Waghray A, Heimberg G, Sikkema L, Kobayashi Y, Dhaval ED, Subramanian A, Smillie C, Jagadeesh K, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber A, Chung H, Montoro D, Adams T, Aliee H, Allon S, Andrusivova Z, Angelidis L, Ashenberg O, Bassier K, Becavin C, Inbal B, Bergenstrahle J, Bergenstrahle L, Bolt L, Braun E, Bui L, Chaffin M, Chichelnitskiy E, Chiou J, Conlon T, Cuoco M, Depre Z, Fisher D, Gillich A, Gould J, Guo M, Gutierrez A, Habermann A, Harvey T, He P, Hou X, Hu L, Jaiswal A, Jiang P, Kapellos T, Kuo C, Larsson L, Leney-Greene M, Lim K, Litvinukova M, Lu J, Maatz H, Maddissoon E, Mamanova L, Manakongtreecheep K, Marquette CH, Mbano I, McAdams AM, Metzger R, Nabhan A, Nyquist S, Ordovas-Montanes J, Penland L, Poirion O, Poli S, Qi C, Reichart D, Rosas I, Schupp J, Sinha R, Sit R, Slowikowski K, Slyper M, Smith N, Sountoulidis A, Strunz M, Sun D, Talavera-Lopez C, Tan P, Tantivit J, Travaglini K, Tucker N, Vernon K, Wadsworth M, Waldman J, Wang X, Yan W, Zhao W, Ziegler C, The NHLBI LungMAP Consortium, The Human Cell Atlas Lung Biological Network. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine 2021, 27(3):546-559.
19. Yu X, Cai B, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang Y, Su X, Wang RF. Cross-Regulation of two type I interferon signaling pathways in plasmacytoid dendritic cells controls anti-malaria immunity and host mortality. Immunity 2016, 45(5):1093-1107.
20. Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J.TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. Molecular Cell 2016, 64(1):105-119.
21. Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, Qin Y, Wang RF, Cui J. USP38 negatively regulates type I interferon signaling by promoting TBK1 degradation through NLRP4 signalosome. Molecular Cell 2016, 64 (2), 267-281.
22. Cui J, Song Y, Li Y, Zhu Q,Tan P, Qin Y, Wang H, Wang RF.USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors. Cell Research 2013, 24:400-416.
承担项目
(1) 国家自然科学基金委员会, 面上项目, 82471794, 探索肠道巨噬细胞亚型介导的神经-免疫互作在炎症诱导的肠蠕动功能障碍中的作用, 2025-01-01 至 2028-12-31，49万元, 在研, 主持
