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何佳成，博士，副研究员，博士生导师，海南省医学科学院青年PI，海南省D类人才。长期致力于G蛋白偶联受体(GPCR)调控肿瘤免疫逃逸的机制解析与靶向GPCR的新药研发，以第一作者或通讯作者(含共同)身份在Nature Immunology (2025), Genes & Diseases (2025), Cell Death & Disease (2022), Journal of Medicinal Chemistry (2022)等国际知名期刊发表SCI论文5篇。承担国家自然科学基金青年项目(C类)，参与多项国家级、省部级科研项目。获得2025年第六届全国肿瘤细胞生物学年会卓越论文称号。
(1) 2013-09 至 2017-06，南京农业大学， 生物工程, 学士
(2) 2017-09 至 2022-06，华东师范大学，生物化学与分子生物学, 博士
(3) 2022-09 至 2025-05，华东师范大学，博士后
(4) 2025-05 至 今，海南医科大学，海南省医学科学院, 副研究员
2025年第六届全国肿瘤细胞生物学年会卓越论文称号
G蛋白偶联受体(GPCR)调控肿瘤免疫逃逸的机制解析与靶向GPCR的新药研发
(1) He Jiacheng#, Chai Xiaolei#, Zhang Qiansen#, Wang Yang#, Wang Yijie, Yang Xinyu, Wu Jingbo, Feng Bo, Sun Jing, Rui Weiwei, Ze Shuyin, Fu Yuanyuan, Zhao Yumiao, Zhang Ying, Zhang Yao, Liu Meizhen, Liu Chuang, She Meifu, Hu Xiangfei, Ma Xueyun, Yang Huaiyu, Li Dawei, Zhao Senlin, Li Guichao, Zhang Zhen, Tian Zhonghui, Ma Yanlin, Cao Lingyan, Yi Bo, Li Dali, Nussinov Ruth, Eng Charis, Chan Timothy A., Ruppin Eytan, Gutkind J. Silvio, Cheng Feixiong, Liu Mingyao*, Lu Weiqiang*. The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer. Nature Immunology, 2025, 26(3): 391-403. (IF=27.6)
(2) Wang Yang#,*, Abuduaini Naijipu#, Liu Wenjuan#, Song Yuanjun, Ke Zunping, Wang Xilong, Jiao Wei, Chen Si, Lin Xianhua, Yu Weiwei, Lu Weiqiang, Feng Bo*, He Jiacheng*. Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells. Genes & Diseases, 2025, 12(3): 101356. (IF=9.4)
(3) Yi Chunyang#, He Jiacheng#, Huang Dan, Zhao Yumiao, Zhang Chan, Ye Xiyun, Huang Ying, Ruth Nussinov, Zheng Junke, Liu Mingyao*, Lu Weiqiang*. Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. Cell Death & Disease, 2022, 13(11): 1004. (IF=9.0)
(4) Wang Wei#, He Jiacheng#, Yang Junjie, Zhang Chan, Cheng Zhiyuan, Zhang Yao, Zhang Qiansen, Wang Peili, Tang Shuowen, Wang Xin, Liu Mingyao, Lu Weiqiang*, Zhang Hankun*. Scaffold hopping strategy to identify prostanoid EP4 receptor antagonists for cancer immunotherapy. Journal of Medicinal Chemistry, 2022,65(11): 7896-7917. (IF=7.3)
(5) He Jiacheng#, Lin Xianhua#, Meng Fanhui#, Zhao Yumiao, Wang Wei, Zhang Yao, Chai Xiaolei, Zhang Ying, Yu Weiwei, Yang Junjie, Li Guichao, Du Xuekui, Zhang Hankun*, Liu Mingyao*, Lu Weiqiang*. A novel small molecular prostaglandin receptor EP4 antagonist, L001, suppresses pancreatic cancer metastasis. Molecules, 2022, 27(4): 1209. (IF=4.6)
(6) Lu Weiqiang#,*, Yu Weiwei#, He Jiacheng, Liu Wenjuan, Yang Junjie, Lin Xianhua, Zhang Yuanjin, Wang Xin, Jiang Wenhao, Luo Jian, Zhang Qiansen, Yang Huaiyu, Peng Shihong, Yi Zhengfang, Ren Shancheng, Chen Jing, Stefan Siwko, Ruth Nussinov, Cheng Feixiong, Zhang Hankun*, Liu Mingyao*. Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer. EMBO Molecular Medicine, 2021, 13(1): e12798. (IF=14.0)
国家自然科学基金青年项目(C类)
