 |
朱才英，1992年出生，医学博士，现任海南医科大学海南省医学科学院副研究员，主要从事造血干细胞调控机制研究，先后在Nature Cell Biology、Blood、Cell Research、Science Immunology等权威期刊发表SCI论文20篇，其中以第一作者（含共同）在Nature Cell Biology（2020，IF=28.8）、Blood（2021, IF=25.7;2025, IF=20.3）发表研究论文3篇，曾获北京协和医学院“协和青年学者支持计划”（2022）、“天津市优秀博士后”（2022）人才项目资助，主持国自然青年科学基金项目（C类）。
学习和工作经历
2024.11 - 至今 海南医科大学（海南省医学科学院）青年PI
2021.09 - 2024.09 中国医学科学院血液病医院（中国医学科学院血液学研究生）博士后
2015.08 - 2021.07 北京协和医学院 博士
2011.08 - 2015.07 天津医科大学 学士
主要获奖情况
2022 协和青年学者支持计划
2022 天津市优秀博士后
课题组结合单细胞多组学、生物信息学方法和动物模型等，对正常和疾病状态下的造血调控、肿瘤耐药复发机制等开展研究。
1. Dong F# , Zhang S# , Zhu C# , Yang Z# , Wang L# , Ma Y, Lu J, Li X, Wang X, Wang N, Zhang S, Xie M, Wang J, Zhang X, Zheng Y, Ma S, Ema H, Cheng H, Hao S, Suda T, Lan Y, Liu B, Zhu P*, Chen J* , Cheng T* . Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of "Super" transplantability. Blood. 2025 Jul 31;146(5):546-557.
2. Cui B# , Ai L# , Lei M# , Duan Y# , Tang C, Zhang J, Gao Y, Li X, Zhu C, Zhang Y, Zhu X, Isobe T, Yang W* , Göttgens B* , Zhu P* . Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemia. Blood. 2025 Mar 13;145(11):1211-1224.
3. Zhang M, Lin X, He J, Zuo Y, Fan Q, Agida I, Tan H, Zhu C, Cheng J*, Wang T**. SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue. Redox Biol. 2025 Sep;85:103752.
4. Zhu C#, Lian Y#, Wang C#, Wu P#, Li X#, Gao Y, Fan S, Ai L, Fang L, Pan H, Cheng T*, Shi J*, Zhu P*. Single-cell transcriptomics dissects hematopoietic cell destruction and T-cell engagement in aplastic anemia. Blood. 2021 Jul 8; 138(1):23-33.
5. Dong F#, Hao S#, Zhang S#, Zhu C#, Cheng H#, Yang Z, Hamey FK, Wang X, Gao A, Wang F, Gao Y, Dong J, Wang C, Wang J, Lan Y, Liu B, Ema H, Tang F, Göttgens B*, Zhu P*, Cheng T*. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nat Cell Biol. 2020 Jun; 22(6):630-639.
6. An S#, Bi H#, Luo X, Zhu C, Wang M, Pang A*, Cui Y*. Identification of key genes of diabetic cardiomyopathy in hiPSCs-CMs based on bioinformatics analysis. Mol Cell Biochem. 2024 Dec; 479(12):3447-3458.
7. Huo Y#, Wu L#, Pang A#, Li Q#, Hong F#, Zhu C, Yang Z, Dai W, Zheng Y, Meng Q, Sun J, Ma S, Hu L, Zhu P, Dong F, Gao X, Jiang E*, Hao S*, Cheng T*. Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation. Sci Immunol. 2023 Mar 17; 8(81):eabn6429.
8. Xia J#, Liu M#, Zhu C, Liu S, Ai L, Ma D, Zhu P, Wang L*, Liu F*. Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. Cell Res. 2023 Jun; 33(6):448-463.
9. Pagliuca S#, Gurnari C#, Hercus C, Hergalant S, Nadarajah N, Wahida A, Terkawi L, Mori M, Zhou W, Visconte V, Spellman S, Gadalla SM, Zhu C, Zhu P, Haferlach T, Maciejewski JP. Molecular landscape of immune pressure and escape in aplastic anemia. Leukemia. 2023 Jan; 37(1):202-211.
10. Gao A#, Xu S#, Li Q, Zhu C, Wang F, Wang Y, Hao S, Dong F, Cheng H, Cheng T, Gong Y. Interlukin-4 weakens resistance to stress injury and megakaryocytic differentiation of hematopoietic stem cells by inhibiting Psmd13 expression. Sci Rep. 2023 Aug 31; 13(1):14253.
11. Yang S#, Sun G#, Wu P#, Chen C#, Kuang Y, Liu L, Zheng Z, He Y, Gu Q, Lu T, Zhu C, Wang F, Gou F, Yang Z, Zhao X, Yuan S, Yang L, Lu S, Li Y, Lv X, Dong F, Ma Y, Yu J, Ng LG, Shi L, Liu J*, Shi L*, Cheng T*, Cheng H*. WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation. J Exp Med. 2022 Apr 4; 219(4):e20211688.
12. Li Y#, Tang C#, Liu F, Zhu C, Liu F, Zhu P*, Wang L*. DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development. 2022; 149(10): dev200390.
13. Hu L#, Yin X#, Zhang Y#, Pang A#, Xie X, Yang S, Zhu C, Li Y, Zhang B, Huang Y, Tian Y, Wang M, Cao W, Chen S, Zheng Y, Ma S, Dong F, Hao S, Feng S, Ru Y, Cheng H, Jiang E, Cheng T. Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage. Blood. 2021 Jun 17; 137(24):3339-3350.
14. Xie M, Zhang S, Dong F, Zhang Q, Wang J, Wang C, Zhu C, Zhang S, Luo B, Wu P, Ema H. Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells. Haematologica. 2021 Jun 1; 106(6):1647-1658.
15. Xie X#, Liu M#, Zhang Y#, Wang B, Zhu C, Wang C, Li Q, Huo Y, Guo J, Xu C, Hu L, Pang A, Ma S, Wang L, Cao W, Chen S, Li Q, Zhang S, Zhao X, Zhou W, Luo H, Zheng G, Jiang E, Feng S, Chen L, Shi L, Cheng H, Hao S*, Zhu P*, Cheng T*. Single-cell transcriptomic landscape of human blood cells. Natl Sci Rev. 2020 Aug 24; 8(3):nwaa180.
16. Yin X#, Hu L#, Zhang Y, Zhu C, Cheng H, Xie X, Shi M, Zhu P, Zhao X, Chen W, Zhang L, Arakaki C, Hao S, Wang M, Cao W, Ma S, Zhang X*, Cheng T*. PDGFB-expressing mesenchymal stem cells improve human hematopoietic stem cell engraftment in immunodeficient mice. Bone Marrow Transplant. 2020 Jun; 55(6):1029-1040.
17. Gao A#, Gong Y#, Zhu C, Yang W, Li Q, Zhao M, Ma S, Li J, Hao S*, Cheng H*, Cheng T*. Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia. Haematologica. 2019 Oct; 104(10):1950-1961.
