个人简介

张铖，青年PI、博士生导师。主要聚焦于肿瘤发生发展机制及其靶向治疗等方面的研究。近年以第一作者或通讯作者（含共同）在Cell Metabolism、Nature Cell Biology、Developmental Cell、Cell Death and Differentiation及Cancer Letters等期刊发表多篇论文。主持高校青年教师科研创新能力支持项目（U40）、国家自然科学基金青年项目、中国博士后科学基金面上项目和肿瘤系统医学全国重点实验室开放课题。获国家博士后创新人才支持计划、国家博士后科研业绩评估考核资助和上海市“超级博士后”等项目。

学习和工作经历

2025.02-至今     海南医科大学（海南省医学科学院）青年PI

2022.07-2025.01  上海交通大学医学院附属仁济医院 博士后

2016.09-2022.06  上海交通大学医学院 博士

2012.09-2016.06  西北农林科技大学 学士

研究方向

 致力于肿瘤发生发展机制及其靶向治疗研究。

代表性论著

1. Ya-Xian Zhong, Huan-Bin Zhao, Meng-Han Lian, Jia-Ming Shen, Cheng-Xiao Li, Hong-Ming Ma, Dan Xu, Guo-Qiang Chen^*, Cheng Zhang^*. SUMOylated hnRNPM suppresses PFKFB3 phosphorylation to regulate glycolysis and tumorigenesis. Cancer Letters, 2025. 616:217573.

2. Chang Liu^#, Cheng Zhang^#, Hongkun Wu^#, Zhibin Zhao^#, Zhenhua Wang, Xiaomin Zhang, Jieli Yang, Wenlong Yu^*, Zhexiong Lian^*, Minghui Gao^*, Lin Zhou^*. The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma. Cell Death and Differentiation, 2025. 32(3): 506-520.

3. Cheng Zhang^#, Hong-Ming Ma^#, Shuai Wu^#, Jia-Ming Shen^#, Na Zhang, Yi-Lu Xu, Cheng-Xiao Li, Ping He, Meng-Kai Ge, Xi-Li Chu, Yu-Xue Zhang, Jun-Ke Zheng, Guo-Qiang Chen^*, Shao-Ming Shen^*. Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression. Developmental Cell, 2024. 59(23): 3072-3088.e8.

4. Xiaolei Huang^#, Cheng Zhang^#, Xinci Shang, Yichang Chen, Qin Xiao, Zhengguo Wei, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Jinrong Min, Shaoming Shen^*, Yanli Liu^*. The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif. Cell Death & Disease, 2024. 15(5): 335.

5. Hefei Ren^#, Chang Liu^#, Cheng Zhang^#, Hongkun Wu, Jiafeng Zhang, Zhenhua Wang, Lei Chen, Huiquan Wang, Chenghao Shao^*, Lin Zhou^*. A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis. Cancer Cell International, 2024. 24:92.

6. Meng-Kai Ge^#, Cheng Zhang^#, Na Zhang, Ping He, Hai-Yan Cai, Song Li, Shuai Wu, Xi-Li Chu, Yu-Xue Zhang, Hong-Ming Ma, Li Xia, Shuo Yang, Jian-Xiu Yu, Shi-Ying Yao, Xiao-Long Zhou, Bing Su^*, Guo-Qiang Chen^*, Shao-Ming Shen^*. The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency. Cell Metabolism, 2023. 35(12): 2216-2230.e8.

7. Ping He^#, Cheng Zhang^#, Yan Ji^#, Meng-kai Ge, Yun Yu, Na Zhang, Shuo Yang, Jianxiu Yu, Shao-Ming Shen^*, Guo-Qiang Chen^*. Epithelial cells-enriched lncRNA SNHG8 regulates chromatin condensation by binding to Histone H1s. Cell Death and Differentiation, 2022. 29(8): 1569–1581.

8. Cheng Zhang, Hong-Ming Ma, Shuang-Shu Dong, Na Zhang, Ping He, Meng-Kai Ge, Li Xia, JianXiu Yu, Qiang Xia, Guo-Qiang Chen^*, Shao-Ming Shen^*. Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role. Cell Death & Disease, 2022. 13(6): 532.

9. Shao-Ming Shen^#*, Cheng Zhang^#, Meng-Kai Ge^#, Shuang-Shu Dong^#, Li Xia, Ping He, Na Zhang, Yan Ji, Shuo Yang, Yun Yu, Jun-Ke Zheng, Jian-Xiu Yu, Qiang Xia, Guo-Qiang Chen^*. PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation. Nature Cell Biology, 2019. 21(11): 1436-1448.

主持承担项目

1. 高校青年教师科研创新能力支持项目（U40），2025-2029

2.  国家自然科学基金青年项目，2024-2026

3. 国家博士后创新人才支持计划，2022-2024

4. 中国博士后科学基金面上项目，2023-2025

5. 上海市”超级博士后“项目，2023-2024

6. 肿瘤系统医学全国重点实验室开放课题，2023-2024