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刘晓叶，青年PI，博士学位，长期致力于肿瘤免疫学的研究，主要围绕1）免疫抑制性细胞在肿瘤微环境中的作用；2）免疫抑制分子在白血病中的功能两方面开展深入研究。以肿瘤微环境中的免疫细胞和白血病细胞为研究对象，应用小鼠模型和临床病人标本，结合生物信息学，分子生物学和生物化学等研究技术，开展肿瘤免疫及白血病发病机制的基础与转化研究，以期为肿瘤免疫治疗提供新的思路和策略。
围绕以上两个研究方向，发表了多篇高水平论文，其中第一作者/共同第一作者文章分别发表在Cancer Immunology Research，Cell Reports，The Journal of Clinical Investigation，Haematologica，Oncotarget。作为共同发明人申请国际专利1项。
2010年9月-2016年6月 中国科学院上海生命科学研究院 生物化学与分子生物学 理学博士
2006年9月-2010年7月 西北农林科技大学 生物技术 理学学士
2025年2月-至今 海南医科大学/海南省医学科学院 青年PI
2023年3月-2025年2月 美国得克萨斯大学西南医学中心 助理讲师
2017年2月-2023年2月 美国得克萨斯大学西南医学中心 博士后
2016年7月-2017年2月 上海交通大学医学院 科研助理
邮箱：liuxiaoye@muhn.edu.cn
1. Ryan Huang#, Xiaoye Liu#, Jaehyup Kim, Hui Deng, Xun Gui, Heyu Chen, Guojin Wu, Wei Xiong, Jingjing Xie, Cheryl Lewis, Jade Homsi, Xing Yang, Chengcheng Zhang, Yubo He, Qi Lou, Carolin Smith, Samuel John, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang. LILRB3 supports immunosuppressive activity of myeloid cells and tumor development. Cancer Immunology Research. 2024;12(3):350–362. (#共同第一作者)
2. Xiaoye Liu#, Feifei Zhang#, Yaping Zhang#, Xie Li#, Chiqi Chen#, Meiyi Zhou, Zhuo Yu, Yunxia Liu, Yuzheng Zhao, Xiaoxin Hao, Yabin Tang, Liang Zhu, Ligen Liu, Li Xie, Hao Gu, Hongfang Shao, Fangzhen Xia, Chunrong Yin, Minfang Tao, Jingjing Xie, Cheng Cheng Zhang, Yi Yang, Haipeng Sun, Guo-Qiang Chen, Junke Zheng. PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of Meis1 and p21. Cell Reports. 2018;23(5):1461–1475. (#共同第一作者)
3. Yaping Zhang#, Fangzhen Xia#, Xiaoye Liu#, Zhuo Yu#, Li Xie, Ligen Liu, Chiqi Chen, Haishan Jiang, Xiaoxin Hao, Xiaoxiao He, Feifei Zhang, Hao Gu, Jun Zhu, Haitao Bai, Cheng Cheng Zhang, Guo-Qiang Chen, Junke Zheng. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling. The Journal of Clinical Investigation. 2018;128(5):1737-1751. (#共同第一作者)
4. Feifei Zhang#, Xiaoye Liu#, Chiqi Chen, Jun Zhu, Zhuo Yu, Jingjing Xie, Li Xie, Haitao Bai, Yaping Zhang, Xia Fang, Hao Gu, Chun Wang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang, Junke Zheng. CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling. Haematologica. 2017;102(4):707-718. (#共同第一作者)
5. Xiaoye Liu#, Xiaoting Yu#, Jingjing Xie, Mengna Zhan, Zhuo Yu, Li Xie, Hongxiang Zeng, Feifei Zhang, Guo-Qiang Chen, Xianghua Yi, Junke Zheng. ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells. Oncotarget. 2015;6(25):21004-15. (#共同第一作者)
6. Xizhen Lian, Sumanta Chatterjee, Yehui Sun, Sean A Dilliard, Stephen Moore, Yufen Xiao, Xiaoyan Bian, Kohki Yamada, Yun-Chieh Sung, Rachel M Levine, Kalin Mayberry, Samuel John, Xiaoye Liu, Caroline Smith, Lindsay T Johnson, Xu Wang, Cheng Cheng Zhang, David R Liu, Gregory A Newby, Mitchell J Weiss, Jonathan S Yen, Daniel J Siegwart. Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells. Nature Nanotechnology. 2024；19:1409–1417.
7. Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ching-Cheng Hsu, Ayman Farag, Nicholas T Lam, Ping Wang, Suwannee Thet, Ivan Menendez-Montes, Waleed M Elhelaly, Xi Lou, Ilaria Secco, Mateusz Tomczyk, Lorena Zentilin, Jimin Pei, Miao Cui, Matthieu Dos Santos, Xiaoye Liu, Yan Liu, David Zaha, Gregory Walcott, Diana R Tomchick, Chao Xing, Cheng Cheng Zhang, Nick V Grishin, Mauro Giacca, Jianyi Zhang, Hesham A Sadek. Identification of FDA-approved drugs that induce heart regeneration in mammals. Nature Cardiovascular Research. 2024;3:372–388.
8. Jingjing Xie, Xun Gui, Mi Deng, Heyu Chen, Yuanzhi Chen, Xiaoye Liu, Zhiqiang Ku, Lingxiao Tan, Ryan Huang, Yubo He, Bruce Zhang, Cheryl Lewis, Kenian Chen, Lin Xu, Jian Xu, Tao Huang, X Charlene Liao, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang. Blocking LAIR1 signaling in immune cells inhibits tumor development. Frontiers in Immunology. 2022;13:996026.
9. Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular Neurodegeneration. 2022;17:44.
10. Guojin Wu, Yixiang Xu, Robbie D Schultz, Heyu Chen, Jingjing Xie, Mi Deng, Xiaoye Liu, Xun Gui, Samuel John, Zhigang Lu, Hisashi Arase, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang. LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2–cFLIP–NF-κB signaling axis. Nature Cancer. 2021;2:1170–1184.
11. Mi Deng, Heyu Chen, Xiaoye Liu, Ryan Huang, Yubo He, Byounggyu Yoo, Jingjing Xie, Samuel John, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang. Leukocyte immunoglobulin-like receptor subfamily B: therapeutic targets in cancer. Antibody Therapeutics. 2021;4(1):16-33.
12. Zunling Li, Mi Deng, Fangfang Huang, Changzhu Jin, Shuang Sun, Heyu Chen, Xiaoye Liu, Licai He, Ali H Sadek, Cheng Cheng Zhang. LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells. Cellular & Molecular Immunology. 2020;17(3):272-282.
13. Heyu Chen, Yuanzhi Chen, Mi Deng, Samuel John, Xun Gui, Ankit Kansagra, Weina Chen, Jaehyup Kim, Cheryl Lewis, Guojin Wu, Jingjing Xie, Lingbo Zhang, Ryan Huang, Xiaoye Liu, Hisashi Arase, Yang Huang, Hai Yu, Wenxin Luo, Ningshao Xia, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang. Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells. Journal for ImmunoTherapy of Cancer. 2020;8(2):e000515.
14. Mi Deng, Xun Gui, Jaehyup Kim, Li Xie, Weina Chen, Zunling Li, Licai He, Yuanzhi Chen, Heyu Chen, Weiguang Luo, Zhigang Lu, Jingjing Xie, Hywyn Churchill, Yixiang Xu, Zhan Zhou, Guojin Wu, Chenyi Yu, Samuel John, Kouyuki Hirayasu, Nam Nguyen, Xiaoye Liu, Fangfang Huang, Leike Li, Hui Deng, Haidong Tang, Ali H Sadek, Lingbo Zhang, Tao Huang, Yizhou Zou, Benjamin Chen, Hong Zhu, Hisashi Arase, Ningshao Xia, Youxing Jiang, Robert Collins, M James You, Jade Homsi, Nisha Unni, Cheryl Lewis, Guo-Qiang Chen, Yang-Xin Fu, X Charlene Liao, Zhiqiang An, Junke Zheng, Ningyan Zhang, Cheng Cheng Zhang. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562(7728):605-609.
15. Maria Jose Costa, Ryan Stafford, Zhiqiang Ku, Jing-Tyan Ma, Krista McCutcheon, Xiaoye Liu, Heyu Chen, Kyu Hong, Tao Huang, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang, X Charlene Liao, An Song. Preclinical characterization of a novel therapeutic antibody targeting LILRB2. Journal for ImmunoTherapy of Cancer. 2020;8(Suppl 3).
16. Fangzhen Xia, Yaping Zhang, Li Xie, Haishan Jiang, Hongxiang Zeng, Chiqi Chen, Ligen Liu, Xiaoxiao He, Xiaoxin Hao, Xia Fang, Xiaoye Liu, Feifei Zhang, Hao Gu, Jiangbo Wan, Yimin Cheng, Cheng Cheng Zhang, Guo-Qiang Chen, Yingli Lu, Zhuo Yu, Junke Zheng. B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways. Leukemia. 2017;10(31):2260-2264.
17. Jia Wang, Minzhi Yin, Kewen Zhao, Fang Ke, Wenjie Jin, Xiaolin Guo, Tianhui Liu, Xiaoye Liu, Hao Gu, Xiaomin Yu, Zhen Li, Lili Mu, Dengli Hong, Jing Chen, Guo-Qiang Chen. APC/C is essential for hematopoiesis and impaired in aplastic anemia. Oncotarget. 2017;8(38):63360.
18. Rongjie Fu, Wei He, Xiaobo Wang, Lei Li, Huanbin Zhao, Xiaoye Liu, Zhi Pang, Guo-Qiang Chen, Lei Huang, Kewen Zhao. DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma. Cell Death & Disease. 2017;8(7):e2952-e2952.
19. Hao Gu, Chiqi Chen, Xiaoxin Hao, Conghui Wang, Xiaocui Zhang, Zhen Li, Hongfang Shao, Hongxiang Zeng, Zhuo Yu, Li Xie, Fangzhen Xia, Feifei Zhang, Xiaoye Liu, Yaping Zhang, Haishan Jiang, Jun Zhu, Jiangbo Wan, Chun Wang, Wei Weng, Jingjing Xie, Minfang Tao, Cheng Cheng Zhang, Junling Liu, Guo-Qiang Chen, Junke Zheng. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. The Journal of Clinical Investigation. 2016;126(12):4537-4553.
20. Hongxiang Zeng, Hao Gu, Chiqi Chen, Minle Li, Fangzhen Xia, Li Xie, Xiaoye Liu, Feifei Zhang, Xuemei Tong, Jiangbo Wang, Zhuo Yu, Junke Zheng. ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways. Oncotarget. 2016;7(25):38347.
21. Fatih Kocabas, Li Xie, Jingjing Xie, Zhuo Yu, Ralph J DeBerardinis, Wataru Kimura, SuWannee Thet, Ahmed F Elshamy, Hesham Abouellail, Shalini Muralidhar, Xiaoye Liu, Chiqi Chen, Hesham A Sadek, Cheng Cheng Zhang, Junke Zheng. Hypoxic metabolism in human hematopoietic stem cells. Cell & Bioscience. 2015;5:1-16.
22. Xuemei Fan, Panlai Shi, Jing Dai, Yeling Lu, Xue Chen, Xiaoye Liu, Kandi Zhang, Xiaolin Wu, Yueping Sun, Kemin Wang, Li Zhu, Cheng Cheng Zhang, Junfeng Zhang, Guo-Qiang Chen, Junke Zheng, Junling Liu. Paired immunoglobulin-like receptor B regulates platelet activation. Blood. 2014;124(15):2421-2430.
23. Junke Zheng, Zhigang Lu, Fatih Kocabas, Ralph T Böttcher, Mercedes Costell, Xunlei Kang, Xiaoye Liu, Ralph J DeBerardinis, Qianming Wang, Guo-Qiang Chen, Hesham Sadek, Cheng Cheng Zhang. Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood. 2014;123(7):992-1001.
