 |
个人简介
谭鹏，博士生导师，海南省医学科学院课题组长。入选广东省 “珠江人才” 青年拔尖人才、海南自由贸易港高层次人才。获美国德克萨斯农工大学与康奈尔大学医学院联合培养博士学位，在麻省理工学院 - 哈佛大学博德研究所 （Broad Institute）完成博士后研究。主要从事固有免疫感知与组织器官区域化神经免疫特征研究，深度参与食物过敏 （FASI）、人类细胞图谱（Human Cell Atlas）等国际大科学计划。主持美国克罗恩病和溃疡性结肠炎基金会（CCFA）SRA 项目、IBD Plexus 项目及国家自然科学基金面上项目。累计发表 SCI 论文 40 篇，总影响因子超 750，谷歌学术总被引 4200 余次；以第一 / 通讯作者发表原创性研究论文 17 篇，成果刊发于Science、Nature Chemical Biology、Nucleic Acids Research、Molecular Cell、Journal of Clinical Investigation等国际权威学术期刊。
学习和工作经历
2025.03-至今 海南医科大学 （海南省医学科学院）
2019.10-2025.03 麻省理工-哈佛博德研究所，霍华德休斯医学研究所，博士后
2018.06-2019.10 康奈尔大学医学院休斯顿卫理公会医院，博士后
2011.09-2018.05 美国德克萨斯农工大学，博士
研究方向
（1）肠道区域化神经编码的分子基础与功能机制研究
（2）肠黏膜区域化神经-免疫互作机制研究
代表性成果
第一作者#，通讯作者*
肠道神经免疫与单细胞空间组学
1. Wu M, Shi H, Biancalani T, Deguine J, Jaiswal A, Regev A, Xavier R*, Tan P*. Spatially-resolved gut atlas cross conditions at molecular level. (In preparation)
2. Tang Z#, Sui X#, Wu M, Tan P, Zhou Y, Shi H, Kawauchiya I, Tian J, Wu M, Xiao L, Huang J, Wang K, Guo J, Lo J, Ren J, Zeng H, Zhou H, Luo S, Zhou Q, Nguyen D, Brown M, Keller K, Zhou X, Li P, Pablo J, Greka A, Xavier R, Lander E, Wang X*.Spatially resolved single-cell atlas of transcriptome and translatome in the adult mouse. Cell (In revision)
3. Tan P#, Jaiswal A#, Murphy S, Su C, Brown E, Hailey W, Finan E, Jasso G, Shi H, Graham D, Delorey T, Deguine J, Xavier R*. Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation. Science 2025, 390(6772):eadr3545.
4. Tan P*, Hong T, Cai X, Li W, Huang Y, He L*, Zhou Y*. Optogenetic control of protein delivery and partitioning in the nucleolus. Nucleic Acids Research 2022, 8;50(12):e69.
5. Shi H, He Y, Zhou Y, Huang J, Maher K, Wang B, Tang Z, Luo S, Tan P, Wu M, Lin Z, Ren J, Thapa Y, Tang X, Liu A, Liu J, Wang X. Spatial atlas of the mouse central nervous system at molecular resolution. Nature 2023, 622(7983):552-561.
光遗传学肠道神经免疫调控
6. Tan P#, He L#, Huang Y*, Zhou Y*. Optophysiology: Illuminating cell physiology with optogenetics. Physiological Reviews 2022,102(3):1263-65.
7. Tan P#, He L#, Han G, Zhou Y. Optogenetic immunomodulation: shedding light on the antitumor immunity. Trends in Biotechnology 2016, 35(3): 215-226.
8. He L#, Tan P#, Zhu L#, Huang K#, Nguyen N, Wang R, Guo L, Li L, Yang Y, Huang Z, Li L, Huang Y, Han G, Wang J, Zhou Y. Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering. Nature Chemical Biology 2021, 17(8):915-923.
9. He L#, Zhang Y#, Ma G#, Tan P#, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan PG, Han G, Zhou Y. Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife 2015, 4: e10024.
10. Jing J, He L, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, Zhou Y. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nature Cell Biology 2015, 17(10):1339-47.
11. He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Fei D, Siwko S, Huang Y, Wang Y, Zhou Y. Engineering of a bona fide light-operated calcium channel. Nature Communications 2021, 12(1):164.
12. Li A, Cho J, Reid B, Tseng C, He L, Tan P, Yeh C, Wu P, Li Y, Widelitz R, Zhou Y, Zhao M, Chow R, Chuong CM. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nature Communications 2018, 9(1):5377.
肠道肿瘤免疫
13. Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang Y, Wang RF. Myeloid loss of Beclin1 promotes PD-L1(hi) precursor B cell lymphoma development. Journal of Clinical Investigation 2020, 129(12):5261-5277.
14. Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, Zhou Y. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biology 2018, 16(11):e3000051.
15. Zhang J#, Tan P#, Guo L#, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao W, Dashwood R, Han L, Zhou Y, Dong W, Huang Y. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene 2018, 38(11):1905-1919.
16. Xing C, Wang M, Ajibade A, Tan P, Fu C, Chen L, Zhu M, Hao Z, Chu J, Yu X, Yin B, Zhu J, Shen W, Duan T, Wang Y, Wang RF. Microbiota regulate innate immune signaling and protective immunity against cancer. Cell Host & Microbe 2021, 29:1-16.
17. Zhu M, Deng G, Tan P, Xing C, Guan C, Jiang C, Ning B, Wang H, Chen K, Zhao Y, Wang Y, Levine B, Nie G, Wang RF. Beclin 2 negatively regulates innate immune signaling and tumor development. Journal of Clinical Investigation 2020, 130(10):5349-5369.
肠道固有免疫感知
18. Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu Xiao, Wang Y, Wang RF. Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling. Molecular Cell 2017, 68 (2): 293-307.
19. Zhu Q#, Tan P#, Li Y, Lin M, Cui J, Zhao W, Song Y, Li Q, Akira S, Wang H, Wang RF. DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity. PLoS Pathogens 2018, 14(2): e1006886.
20. Muus C, Luecken M, Eraslan G, Waghray A, Heimberg G, Sikkema L, Kobayashi Y, Dhaval ED, Subramanian A, Smillie C, Jagadeesh K, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber A, Chung H, Montoro D, Adams T, Aliee H, Allon S, Andrusivova Z, Angelidis L, Ashenberg O, Bassier K, Becavin C, Inbal B, Bergenstrahle J, Bergenstrahle L, Bolt L, Braun E, Bui L, Chaffin M, Chichelnitskiy E, Chiou J, Conlon T, Cuoco M, Depre Z, Fisher D, Gillich A, Gould J, Guo M, Gutierrez A, Habermann A, Harvey T, He P, Hou X, Hu L, Jaiswal A, Jiang P, Kapellos T, Kuo C, Larsson L, Leney-Greene M, Lim K, Litvinukova M, Lu J, Maatz H, Maddissoon E, Mamanova L, Manakongtreecheep K, Marquette CH, Mbano I, McAdams AM, Metzger R, Nabhan A, Nyquist S, Ordovas-Montanes J, Penland L, Poirion O, Poli S, Qi C, Reichart D, Rosas I, Schupp J, Sinha R, Sit R, Slowikowski K, Slyper M, Smith N, Sountoulidis A, Strunz M, Sun D, Talavera-Lopez C, Tan P, Tantivit J, Travaglini K, Tucker N, Vernon K, Wadsworth M, Waldman J, Wang X, Yan W, Zhao W, Ziegler C, The NHLBI LungMAP Consortium, The Human Cell Atlas Lung Biological Network. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine 2021, 27(3):546-559.
21. Yu X, Cai B, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang Y, Su X, Wang RF. Cross-Regulation of two type I interferon signaling pathways in plasmacytoid dendritic cells controls anti-malaria immunity and host mortality. Immunity 2016, 45(5):1093-1107.
22. Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses. Molecular Cell 2016, 64(1):105-119.
23. Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, Qin Y, Wang RF, Cui J. USP38 negatively regulates type I interferon signaling by promoting TBK1 degradation through NLRP4 signalosome. Molecular Cell 2016, 64 (2), 267-281.
24. Cui J, Song Y, Li Y, Zhu Q,Tan P, Qin Y, Wang H, Wang RF. USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors. Cell Research 2013, 24:400-416.
承担项目
(1) 国家自然科学基金委员会面上项目（82471794），探索肠道巨噬细胞亚型介导的神经-免疫互作在炎症诱导的肠蠕动功能障碍中的作用，2025-01-01 至 2028-12-31，49万元，在研，主持
